Differential Diagnosis of Restricted Diffusion Confined to the Cerebral Cortex

Review of diffuse cortical injury on diffusion-weighted imaging in acutely encephalopathic patients with an acronym: “CRUMPLED”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231053/

Yasemin Koksel, John Benson, Haitao Huang, Mehmet Gencturk, and Alexander M. McKinney

Acute encephalopathic syndromes can present a diagnostic challenge due to the wide range of possible etiologies, which also can have vastly different outcomes. The presence of diffuse cortical injury (DCI) on diffusion-weighted imaging (DWI) can help narrow the differential diagnosis. The aim of this review is to categorize the range of possible etiologies of DCI into a useful acronym, “CRUMPLED”.